学术沙龙

学术沙龙第二十三期:鸡独特的抗禽流感病毒天然免疫策略

发布时间:2021-07-09 

报 告 人:程玉强   赌博十大网站平台动物科学系 副研究员

   间:2021年7月14日 (星期三) 12:40-14:00

   点:赌博十大网站平台创新楼(B楼)104会议室

主办单位:赌博十大网站平台学科与科技办、赌博十大网站平台青年教师联谊会

 

 

 

报告题目:鸡独特的抗禽流感病毒天然免疫策略

报告摘要:

鸡是禽流感病毒(AIV)跨宿主感染人的重要媒介,其对高致病性AIV高度易感且表现出极高死亡率。传统理论认为“RIG-I、IRF3等天然免疫基因缺失导致鸡免疫力严重缺陷,是鸡对AIV易感、高死亡率的关键原因”。报告人课题组研究发现,尽管鸡天然免疫基因容量较哺乳动物小,且缺失了多个关键天然免疫分子,其能充分利用有限的资源,通过“基因多功能化”、“重构代偿旁路”等多种方式形成独特的天然免疫防御网络,参与AIV免疫应答。结合他人研究,报告人提出:鸡对AIV的天然免疫应答毫不逊色,相反,鸡具有更强的天然免疫应答能力,其感染病毒后引起的天然免疫过度激活或才是其感染AIV高死亡的真正原因。

 

报告人简介:

报告人2016年获上海交通大学生物医学工程博士学位,2016-2018年上海交通大学从事博士后研究,2018年7月入职赌博十大网站平台。

【PI学科组研究方向】:

报告人所属学科团队PI为孙建和教授,团队研究方向:

(1)禽抗病毒天然免疫;

(2)动物比较免疫学

 

 

ACADEMIC SALON (XXIII)

SPEAKER: Yuqiang Cheng

Associate Professor

Department of Animal Science, SAB

 

TIME :12:40-14:00 July 14, 2021

VENUE:Room 104, Building B, SAB

ORGANIZER:Office of Discipline and Science & Technology, SAB;

Young Teachers Association, SAB

TITLE:

Unique innate immunity strategies against avian influenza virus in chickens

ABSTRACT:

Chickens are highly susceptible to highly pathogenic avian influenza virus (AIV) and show a high mortality after AIV infection, and they act as the cross host vectors of AIV to infect humans. According to the traditional theory, "the natural missing of innate immune genes, such as RIG-I and IRF3, leads to severe immune deficiency in chickens, which is the key reason for the susceptibility and high mortality of chickens to AIV." The reporter's group found that although the capacity of chicken innate immune genes is smaller than that of mammals, and they lacks many key innate immune molecules, they employ a series of strategies to form an unique innate immune defense networks to participate in anti-AIV immune response. Combined with other reports, the reporter concluded that the innate immune system of chickens is not inferior. In actually, chickens have a stronger innate immune response, and the over activation of innate immunity by the infection of AIV may be the real cause of its high mortality to AIV.

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